Disrupted sleep-wake cycle might be a measure for preclinical Alzheimer’s.

National Institute of Health – National Institute on Aging - Report - Disrupted sleep-wake cycle might be a measure for preclinical Alzheimer's - People with dementia due to Alzheimer’s disease are known to have disrupted sleep. New NIH-funded research, published online Jan. 29, 2018, in JAMA Neurology, links a disrupted sleep-wake cycle to an earlier, preclinical disease phase, in which people have evidence of the disease but no symptoms. The study, by researchers at the Knight Alzheimer's Disease Research Center at Washington University in St. Louis, Missouri, suggests that a fragmented sleep-wake cycle might be explored as a biomarker for preclinical Alzheimer's.